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This is a rare, severe and multiorgan reaction found frequently associated with antiepileptic agents (phenytoin, carbamazepine, phenobarbital, lamotrigine) allopurinol, dapsone and sulfonamides.1,2 WHO defines adverse drug reactions to medications as an unintended response to a noxious drug and which occurs when administered at normally used doses in humans for prophylaxis, diagnosis or disease treatment or for modification of a physiological function.3 DRESS syndrome is distinguished by the clinical triad of fever, rash and multiorgan involvement.4 The pathology is partially known as different mechanisms have been implicated in its development.5 It has been reported that there could be an immunological phenomenon involved in its origin that causes the release of cytokines by the T-lymphocytes and activation of macrophages.6 Other mechanisms include defects in detoxification that lead to the formation of reactive metabolites and subsequent immunological reactions, of slow acetylation and reactivation of human herpes, including types 6 and 7 (HHV-6 and HHV-7), and of the Epstein-Barr virus.7 DRESS syndrome is of late beginning and with slow evolution and is clinically similar to infectious processes, for which it is frequently misdiagnosed.8 Its incidence varies from 1/1,000-1/10,000 of individuals exposed to different drugs.5 Correct diagnosis is difficult due to the variety of clinical and laboratory abnormalities
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